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2006-10-15 News Release

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Enthusiastic response for boron chemistry conference

Around 100 international scientists and experts exchanged views about the latest developments in the field of boron chemistry at a recent conference in Tokyo.

The second international BASF Boron Conference held recently in Tokyo met with an enthusiastic response from international scientists and experts.

“With the boron conference we offer a platform for open discussions and scientific exchange as a means of establishing contacts between scientists from institutes and industry, and especially our customers. In this way we aim to further promote the industrial use of boron chemistry”, emphasized Dr. Ulrich Bueschges, Group Vice President Inorganic Specialties at BASF Aktiengesellschaft in Ludwigshafen, Germany.

Find Information and Suppliers of boron compounds.

“From lab to launch – discover new horizons” was the motto of the two-day conference attended by scientists from academia and institutes, industrial research and development and representatives of customers who use boron chemistry. In total, specialists representing 56 international companies from eight countries attended the event. Numerous examples of successful commercial applications of boron compounds were presented. One main focus of the conference was the use of boron reagents in active ingredient synthesis. The conference focused on cross-coupling reactions, stereo- and regioselective reactions with boranes and new applications from borane chemistry.

“No other conference so successfully brings together academic scientists and experts from industry working in the boron chemistry field,” said Prof. Akira Suzuki, Hokkaido University, Japan.

“Sixty years ago, there were only two laboratories in the world capable of producing small amounts of diborane. Today, some of the best selling medications are produced with the aid of organoboranes,” explained Dr. Carsten Blettner, Business Development Manager East Asia at BASF’s Regional Headquarters in Hong Kong.

These inorganic chemicals used for selective reduction and hydro boration and the new boron products, support Suzuki coupling reaction. image. photo: BASF

The plenary lectures of the second BASF boron conference were held by Professor Akira Suzuki and Professor Norio Miyaura of Hokkaido University, Japan. “It is only logical that the numerous advantages of the Suzuki-Miyaura coupling have not only been widely used in academic research, but have also found industrial applications,” concluded Professor Suzuki. BASF now operates the world’s largest plant for Suzuki-Miyaura couplings to produce the new fungicide boscalid in Guaratingueta, Brazil. Professor Miyaura emphasized further reactions with boric acids during his presentation.

Amine borane complexes, which can be used to perform particularly selective reductions, were discussed in detail by Prof. Yasuo Kikugawa of Josai University, Japan: “Amine boranes are easy to handle, relatively nontoxic and have high stability,” he emphasized. A particularly interesting aspect is that the chemical reactivity of the reducing agent can be adjusted to match exactly the structure of the target molecule because of the large number of available amine-borane complexes. Kikugawa placed special emphasis on the advantages of picoline-borane, which is produced in commercial quantities by BASF.

In one of the decisive steps of the synthesis of coenzyme Q10 developed by Professor Sangho Koo, Myong Ji University, Korea, boron reagent LiBHEt3 (Lithium triethylborohydride, CALSELECT* LT, in Tetrahydrofuran) has proved the most successful. Developed in the late 1990s as a laboratory synthesis, this process is now used successfully on a commercial scale and is being constantly refined. CALSELECT Reducing Agents (inorganics chemicals) are also known as, tri-substituted borohydrides.

The rapid advances in boron chemistry and its use in pharmaceutical chemistry in the last 35 years were described by Dr. Om Reddy, Orchid Chemicals, India. “Boron reagents are excellent auxiliaries for process development,” said Dr. Karl Matos, BASF Corporation, Evans City, Pennsylvania. “They allow the synthesis of complex molecular structures with high selectivities and excellent yields.” This assessment was supported by Dr. Keshav Deo, Ranbaxy Research Laboratories, India.

The increasing commercial use of palladium-catalyzed borylation with pinacol boranes, such as PinB and Pin2B2 offered by BASF, was given due prominence in a presentation of new catalyst systems by Dr. Miki Murata, Kitami Institute of Technology, and Dr. Mayumi Nishida, Koei Chemical Company, Japan, and in a discussion of improved reagent systems by Akihiko Kojima. Palladium-catalyzed borylation with pinacol boranes is an addition to the Suzuki-Miyaura reaction and often makes it possible to reduce the number of process steps and achieve better results compared to conventional methods.

BASF is the market leader in the development and production of boron reagents for commercial organic synthesis. The company cooperates closely with its customers in developing improved methods of synthesis for complex new molecules. Typical applications of boron reagents are found in the synthesis of active ingredients, OLED displays, as well as fine and special chemicals.

BASF’s innovative portfolio of products includes highly selective boron reagents for reductions and hydroborylations as well as catalysts for asymmetrical synthesis, and also, alkali metals and arcorate used as strong base or catalyst, borane (hydroxide boron). A further highlight is the class of reagents for Suzuki couplings. BASF's inorganic speciality chemicals are providing efficient added value to products for use as reactive supplementary agents, additives and reagents for reactions as well as for building blocks by various industries.

BASF produces boron specialties in Evans City, Pennsylvania, a site equipped with a wide array of experimental and production facilities. This allows the company to increase the production of reagents rapidly and in response to demand, in order to satisfy customers’ requirements for small or large quantities from the development stage up to market launch of the product.

* Calselect is a registered trademark of BASF.

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Read a recent press release about - Due to increased costs for raw materials, transportation, energy and packaging, BASF raises prices worldwide for coating resins as existing contracts allow.

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