Mixing Chamber - Surgeons use the Plexis™ Bone Void Filling System to mix and deliver biomaterials during skeletal-related procedures. The clear COC mixing chamber allows them to see when the biomaterial is fully mixed. The narrower COC syringe body attached to the chamber delivers the biomaterial to a delivery tube that carries the biomaterial to the point of application.

Press Release-December 17, 2004-Jobwerx News-Advanced Biomaterial Systems Selects Topas® COC in Biomaterial Delivery Device to Gain Clarity, Chemical Resistance

Advanced Biomaterial Systems has chosen Topas® cyclic olefin copolymer (COC) from Ticona, the technical polymers business of the Celanese Group, for the mixing chamber and syringe in its Plexis™ Bone Void Filling System, which is used by surgeons to mix and deliver biomaterials during skeletal-related procedures. The COC was selected for its clarity, chemical resistance, dimensional stability and ability to withstand gamma sterilization.

Topas COC was selected over such clear resins as polycarbonate, polystyrene and acrylic because it does not react with certain biomaterials. The polymer holds accurate dimensions during molding and in use to retain the tight tolerance needed between the mixing chamber and the paddles.

The mixing chamber, which is a cylinder approximately 2 inches in diameter and 4 inches long, is part of a hand-operated mixer that prepares and delivers the company’s proprietary biomaterials, including its Concert® Cranioplast material.

The Plexis™ syringe body, which is attached to the mixing chamber, is 3 in. long and 0.75 in. in diameter. It is molded with just 0.0625° draft per side, so the plunger forms a tight seal as it moves, and is printed with milliliter markings after processing. The syringe has a molded-in Luer fitting for a delivery tube and cannula that carries the cement to the point of application.

Filling System - The Plexis™ Bone Void Filling System from Advanced Biomaterial Systems uses Topas® cyclic olefin copolymer (COC) from Ticona to give the mixing chamber and syringe body attached to it (center of image) high clarity, chemical resistance to the biomaterials used and dimensional stability.

“The COC’s glass-like clarity allows surgeons to see when the biomaterial is fully mixed and to gauge the amount of biomaterial delivered to the site,” says John Carr, Chief Operating Officer of Advanced Biomaterials Systems. “The resin withstands pressures in the syringe that can approach 1,200 psi as the plunger moves the biomaterial down the syringe and through the cannula. It also has the USP Class VI certification we need in a delivery system that will not react with the biomaterial.”

The Plexis™ system is sold as a sterile product that mixes and delivers biomaterials, including PMMA bone cement used to stabilize fractures and fill areas of bone loss. Plexis™ mixes and delivers biomaterials in the same unit, which eliminates the need for separate syringes, bowls, tubes or injectors.

For more information
Advanced Biomaterial Systems, Inc. was founded in 1994 and is a leading provider of biomaterial mixing and delivery systems. Its products, which include twistOR PrePack™ with Concert® bone cement and delivery systems, have advanced the development and delivery of biomaterials to treat musculoskeletal sites damaged by disease, infection or trauma.

For information about Advanced Biomaterial Systems’ products, contact: Advanced Biomaterial Systems, Inc., 100 Passaic Avenue, Chatham, NJ 07928, Phone: 973-635-9040. Fax: 973-635-9878. E-mail: pvansyckle@advbiomat.com. Or search Google above for: advbiomat.com

For information on Topas® COC for use in biomedical and other applications, contact: Ticona, 8040 Dixie Highway Florence, KY 41042, USA. Phone: 1-800-833-4882. Email: prodinfo@ticona.com. In Europe: Ticona GmbH, Professor-Staudinger-Straße, D-65451 Kelsterbach, Germany. Phone: +49-(0)180-584-2662 (DE) or +49-(0)693-051- 6299 (EU). Email: infoservice@ticona.de. Or search Google above for: ticona.com


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